Watch Intently (3)pentobarbital will lower the level or effect of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Sturdy or reasonable CYP3A4 inducers may improve charge of diazepam elimination; therefore, efficacy of diazepam might be lowered.pentobarbital will reduce the level or impact of